Peptide Database

Peptide NameSLAY-screened peptide P546

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length16 amino acids

Chemical FormulaC76H119N23O24S

DescriptionStandard

        TTYCLRSPNAPSPNIH
    

Molecular Weight1770.96 Da

Isoelectric Point (pI)7.92

Net Charge (pH 7.0)0.47

Net Charge (pH 7.4) 0.22

Charge Density (pH 7.0) 0.0297

GRAVY Index-0.70

Hydrophobic Moment 0.38

Boman Index-0.06

Instability Index175.09

Aliphatic Index 55.00

Aromaticity 0.0625

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 751.36

LogP -10.09

H-bond Donors 26.0

H-bond Acceptors 27.0

Rotatable Bonds 49.0

Heavy Atoms 124.0

Ring Count 5.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0139081 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/