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MYP_124219
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Basic Information
Brevinin-1CG4
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
24 amino acids
C123H209N29O31S2
Standard
Sequence
FLSTLLNVASKVVPTLFCKITKKC
Physicochemical Analysis
2654.28 Da
9.70
3.74
3.50
0.1557
0.85
0.56
0.22
10.53
121.67
0.0833
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
972.15
-6.86
36.0
37.0
88.0
185.0
3.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0320238 VERIFIED: YES
Provenance & Taxonomy
Chungan torrent [Animal]
Brevinin
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial
PMID22951323 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22951323/
RECORD: Rec_0359514 VERIFIED: YES
Provenance & Taxonomy
Amolops chunganensis [Animal] [Animal]; Amolops granulosus [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-negative
Escherichia coli
150 μM
MIC
RECORD: Rec_0377702 VERIFIED: YES
Provenance & Taxonomy
Amolops chunganensis [Animal]
Brevinin
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida albicans (ATCC 10231)
150 μM
MIC
PMID22951323 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22951323/
RECORD: Rec_0401053 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Toxic Anti-Gram-positive Cytotoxic Anti-Gram-negative
PaperDADP: the database of anuran defense peptides PMID22467909 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467909/
RECORD: Rec_0402707 VERIFIED: YES
Provenance & Taxonomy
Amolops granulosus [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
18-24
Bio-Activity Profile
Antimicrobial Antibacterial
PaperJ.M. Conlon et al. / Peptides 28 (2007) 1268-1274. Peptide defenses of the Cascades frog Rana cascadae: implications for the evolutionary history of frogs of the Amerana species group PMID17451843 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17451843/
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