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MYP_124195
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Basic Information
PR-39
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Wound healing/Regeneration ▸ Wound healing
Standard
39 amino acids
C229H345N69O41
Standard
Sequence
RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPRFP
Physicochemical Analysis
4720.63 Da
12.00
9.76
9.55
0.2502
-1.31
0.62
-0.33
118.68
30.00
0.1538
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1641.34
-8.00
52.0
51.0
116.0
339.0
25.0
38.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0105375 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Natural peptide
9823
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antimycobacterial Antibacterial
Mycobacterium tuberculosis E1380/94 (MDR resistant stain)
50 μg/mL
IC50
PMID25681127 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25681127/
RECORD: Rec_0107734 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 17.9%, C 82.1% [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Antibacterial Antimicrobial Anti-Gram-positive Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0136866 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Natural peptide
9823
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
Amidation
Bio-Activity Profile
Antimicrobial Antimycobacterial Antibacterial
Mycobacterium tuberculosis #894-D11 streptomycin resistant strain
50 μg/mL
MIC
PMID11328767 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11328767/
RECORD: Rec_0141173 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Cathelicidin
9823
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antimalarial Antiparasitic
Plasmodium falciparum 3D7
Growth inhibition; ELISA (HRP-II levels detection)
PaperComprehensive study of proteasome inhibitors against Plasmodium falciparum laboratory strains and field isolates from Gabon PMID18816382 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18816382/
RECORD: Rec_0141643 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Cathelicidin
9823
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anticancer Wound healing
P-aeruginosa ATCC 27853
>32 μg/mL
MIC
PaperAmino acid sequence of PR-39. Isolation from pig intestine of a new member of the family of proline-arginine-rich antibacterial peptides PMID30641213 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30641213/
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