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MYP_124178
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Basic Information
Gradimycin
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
19 amino acids
C81H132N20O27S4
Standard
Sequence
SSGWVCTLTIECGTVICAC
Physicochemical Analysis
1946.29 Da
4.05
-1.58
-1.84
-0.0830
1.27
0.17
0.44
103.71
97.37
0.0526
5500.00
5750.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
741.36
-8.71
31.0
30.0
59.0
132.0
2.0
18.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0314581 VERIFIED: NO
Provenance & Taxonomy
Bacteria [Bacterium]
2
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0324480 VERIFIED: YES
Provenance & Taxonomy
Actinoplanes garbadinensis [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus MetS ATCC 6538P
32 μg/mL
MIC
PaperGardimycin, a new antibiotic from Actinoplanes. III. Biological properties
RECORD: Rec_0333928 VERIFIED: YES
Provenance & Taxonomy
Actinoplanes garbadinensis [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Enterococcus faecalis VanS L559 or VanA L560
128 μg/mL
MIC
PaperGardimycin, a new antibiotic from Actinoplanes. III. Biological properties
RECORD: Rec_0353202 VERIFIED: YES
Provenance & Taxonomy
Actinoplanes garbadinensis [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0367913 VERIFIED: YES
Provenance & Taxonomy
Actinoplanes garbadinensis [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Escherichia coli ATCC 25922
>128 μg/mL
MIC
PaperGardimycin, a new antibiotic from Actinoplanes. III. Biological properties
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