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MYP_124114
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Basic Information
Rapakinin - anti-inflammatory peptide
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ COX-2 Inhibitory
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Regulatory peptide ▸ Biological regulation
Standard
3 amino acids
C21H34N6O5
Standard
Sequence
RIY
Physicochemical Analysis
450.53 Da
8.75
0.76
0.55
0.2530
-0.43
1.09
-0.30
6.67
130.00
0.3333
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
203.65
-0.37
8.0
6.0
13.0
32.0
1.0
2.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0210133 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
PaperYamada Y., Iwasaki M., Usui H., Ohinata K., Marczak E. D., Lipkowski A. W., Yoshikawa M.. Rapakinin, an anti-hypertensive peptide derived from rapeseed protein, dilates mesenteric artery of spontaneously hypertensive rats via the prostaglandin IP receptor followed by CCK1 receptor. Peptides, 31, 909-914, 2010.
RECORD: Rec_0227096 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antioxidant
PaperWang Z., Rivas-Serna I. M., Monirujjaman, Fernando I. P. S., Mazurak V. C., Wu J.. Anti-inflammatory and antioxidative effects of bioactive peptides IKW and RIY in spontaneously hypertensive rats and angiotensin II-stimulated vascular smooth muscle cells. Food Biosci., 62, 105417, 2024.
RECORD: Rec_0228633 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anti-inflammatory COX-2 Inhibitory
Cyclooxygenase-2 (COX-2)
PaperWang Z., Rivas-Serna I. M., Monirujjaman, Fernando I. P. S., Mazurak V. C., Wu J.. Anti-inflammatory and antioxidative effects of bioactive peptides IKW and RIY in spontaneously hypertensive rats and angiotensin II-stimulated vascular smooth muscle cells. Food Biosci., 62, 105417, 2024.
RECORD: Rec_0246884 VERIFIED: YES
Provenance & Taxonomy
Brassica napus [Plant]
Angiotensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Enzyme inhibitory ACE inhibitory
Angiotensin-converting enzyme
28 μM
IC50
RECORD: Rec_0247793 VERIFIED: YES
Provenance & Taxonomy
Brassica napus [Plant]
ACE-inhibitory peptide
3708
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
ACE
28 μM
IC50
PaperGlycinyl-Histidinyl-Serine (GHS), a Novel Rapeseed Protein-Derived Peptide Has Blood Pressure-Lowering Effect in Spontaneously Hypertensive Rats PMID23919612 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23919612/
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