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MYP_124114
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Basic Information
Rapakinin - anti-inflammatory peptide
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ COX-2 Inhibitory
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Regulatory peptide ▸ Biological regulation
Standard
3 amino acids
C21H34N6O5
Standard
Sequence
RIY
Physicochemical Analysis
450.53 Da
8.75
0.76
0.55
0.2530
-0.43
1.09
-0.30
6.67
130.00
0.3333
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
203.65
-0.37
8.0
6.0
13.0
32.0
1.0
2.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0210133 VERIFIED: YES
Provenance & Taxonomy
Brassica napus [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
mesenteric artery from spontaneously hypertensive rats
5.1 μM
vasorelaxation EC50 assay
PaperYamada Y., Iwasaki M., Usui H., Ohinata K., Marczak E. D., Lipkowski A. W., Yoshikawa M.. Rapakinin, an anti-hypertensive peptide derived from rapeseed protein, dilates mesenteric artery of spontaneously hypertensive rats via the prostaglandin IP receptor followed by CCK1 receptor. Peptides, 31, 909-914, 2010. PMID20188776
RECORD: Rec_0227096 VERIFIED: YES
Provenance & Taxonomy
Brassica napus [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antioxidant
spontaneously hypertensive rats and angiotensin II-stimulated vascular smooth muscle cells
in vivo rat and in vitro vascular-smooth-muscle-cell anti-inflammatory/antioxidant assays
PaperWang Z., Rivas-Serna I. M., Monirujjaman, Fernando I. P. S., Mazurak V. C., Wu J.. Anti-inflammatory and antioxidative effects of bioactive peptides IKW and RIY in spontaneously hypertensive rats and angiotensin II-stimulated vascular smooth muscle cells. Food Biosci., 62, 105417, 2024.
RECORD: Rec_0228633 VERIFIED: YES
Provenance & Taxonomy
Brassica napus [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anti-inflammatory COX-2 Inhibitory
cyclooxygenase-2 in angiotensin II-stimulated vascular smooth muscle cells
in vitro COX-2/inflammatory-response assay in AngII-stimulated vascular smooth muscle cells
PaperWang Z., Rivas-Serna I. M., Monirujjaman, Fernando I. P. S., Mazurak V. C., Wu J.. Anti-inflammatory and antioxidative effects of bioactive peptides IKW and RIY in spontaneously hypertensive rats and angiotensin II-stimulated vascular smooth muscle cells. Food Biosci., 62, 105417, 2024.
RECORD: Rec_0246884 VERIFIED: YES
Provenance & Taxonomy
Brassica napus [Plant]
Angiotensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Enzyme inhibitory ACE inhibitory
Angiotensin-converting enzyme
28 μM
IC50
PMID12948830
RECORD: Rec_0247793 VERIFIED: YES
Provenance & Taxonomy
Brassica napus [Plant]
ACE-inhibitory peptide
3708
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
Angiotensin-converting enzyme (ACE)
28 μM
IC50
PaperNew antihypertensive peptides isolated from rapeseed PMID12948830 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23919612/
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