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MYP_124114
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Basic Information
Rapakinin - anti-inflammatory peptide
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ COX-2 Inhibitory
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Regulatory peptide ▸ Biological regulation
Standard
3 amino acids
C21H34N6O5
Standard
Sequence
RIY
Physicochemical Analysis
450.53 Da
8.75
0.76
0.55
0.2530
-0.43
1.09
-0.30
6.67
130.00
0.3333
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
203.65
-0.37
8.0
6.0
13.0
32.0
1.0
2.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0017625 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anti-inflammatory
PaperWang Z., Rivas-Serna I. M., Monirujjaman, Fernando I. P. S., Mazurak V. C., Wu J.. Anti-inflammatory and antioxidative effects of bioactive peptides IKW and RIY in spontaneously hypertensive rats and angiotensin II-stimulated vascular smooth muscle cells. Food Biosci., 62, 105417, 2024.
RECORD: Rec_0077467 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Opioid Antagonist
opioid receptor
PaperYamada Y., Ohinata K., Lipkowski A. W., Yoshikawa M.. Rapakinin, Arg-Ile-Tyr, derived from rapeseed napin, shows anti-opioid activity via the prostaglandin IP receptor followed by the cholecystokinin CCK2 receptor in mice. Peptides, 32, 281-285, 2011.
RECORD: Rec_0115207 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
ACE
20000 μM
IC50
PaperStructural requirements of Angiotensin I-converting enzyme inhibitory peptides: quantitative structure-activity relationship study of di- and tripeptides. PMID16448176 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16448176/
RECORD: Rec_0131874 VERIFIED: NO
Provenance & Taxonomy
Brassica napus [Plant]
ACE-inhibitory peptide
3708
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
Spontaneously hypertensive rat (SHR)
11.3 mmHg
SBP decrease
PaperAntihypertensive peptides from food proteins: a review. PMID22249830 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22249830/
RECORD: Rec_0144953 VERIFIED: YES
Provenance & Taxonomy
Brassica napus [Plant]
ACE inhibitory peptide
3708
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
ACE inhibitory Antihypertensive
Angiotensin-converting enzyme
28 μM
IC50
PaperPubMed PMID 17430180 | PubMed PMID 20188770 PMID17430180;20188770 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17430180/
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