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MYP_124113
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Basic Information
Tric[K2]
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
11 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XKLXGGLXGIX
Physicochemical Analysis
0.00 Da
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0007739 VERIFIED: YES
Provenance & Taxonomy
Ascomycetes [Fungus]
Structure & Mods
helical peptaibol [Linear]
noncanonical stereochemical modification [Modified]
n-Octanoyl
Leucinol
N-terminal n-octanoyl; Aib at residues 1,4,8; Gly2→Lys substitution; C-terminal leucinol
Bio-Activity Profile
Antimicrobial Anticancer
-
PMID25306964 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25306964/
RECORD: Rec_0063019 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
helical peptaibol [Linear]
noncanonical stereochemical modification [Modified]
n-Octanoyl
Leucinol
N-terminal n-octanoyl; Aib at residues 1,4,8; Gly2→Lys substitution; C-terminal leucinol
Bio-Activity Profile
Hemolytic
human erythrocytes
4 μM
Hemolysis
PMID25306964 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25306964/
RECORD: Rec_0115247 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
helical peptaibol [Linear]
noncanonical stereochemical modification [Modified]
n-Octanoyl
Leucinol
N-terminal n-octanoyl; Aib at residues 1,4,8; Gly2→Lys substitution; C-terminal leucinol
Bio-Activity Profile
Antimicrobial Antibacterial
Human epidermoid carcinoma A431
6 μM
EC50
PMID25306964 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25306964/
RECORD: Rec_0124091 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
helical peptaibol [Linear]
noncanonical stereochemical modification [Modified]
n-Octanoyl
Leucinol
N-terminal n-octanoyl; Aib at residues 1,4,8; Gly2→Lys substitution; C-terminal leucinol
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa
58 μM
MIC
PMID25306964 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25306964/
RECORD: Rec_0132401 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
helical peptaibol [Linear]
noncanonical stereochemical modification [Modified]
n-Octanoyl
Leucinol
N-terminal n-octanoyl; Aib at residues 1,4,8; Gly2→Lys substitution; C-terminal leucinol
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus epidermidis
4.3 μM
MIC
PMID25306964 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25306964/
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