Peptide Database

Peptide Name[D-Trp6]-LHRH (Luteinizing hormone-releasing hormone)

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Standard StatusStandard

Sequence Length10 amino acids

Chemical FormulaC71H89N17O16

DescriptionStandard

        PYREHWSYWL
    

Molecular Weight1436.57 Da

Isoelectric Point (pI)7.17

Net Charge (pH 7.0)0.05

Net Charge (pH 7.4) -0.07

Charge Density (pH 7.0) 0.0046

GRAVY Index-1.42

Hydrophobic Moment 0.29

Boman Index-0.05

Instability Index-16.36

Aliphatic Index 39.00

Aromaticity 0.4000

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 13980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 531.38

LogP -0.34

H-bond Donors 21.0

H-bond Acceptors 17.0

Rotatable Bonds 39.0

Heavy Atoms 104.0

Ring Count 8.0

Amide Bonds 9.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0276898 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

N-TermNone

C-TermAmidation

Other ModsPyr=Pyro-glutamic acid

Bio-Activity Profile

Function

Luteinizing hormone release

MethodHPLC

Half-LifeTwo male Beagle dogs plasma (Dose s/c injected), in vivo; >5040 s