Peptide Database

Peptide NameVenom peptide 2a (EpVP2a) (VP2a) (Eumenine mastoparan VP2a)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Standard StatusStandard

Sequence Length63 amino acids

Chemical FormulaC299H476N74O83S

DescriptionStandard

        MRGTSFILFAVVVILGFLNANAEPLANPAPLANPDPLANPDPLANPEAFDLLGLVKKVASALG
    

Molecular Weight6467.49 Da

Isoelectric Point (pI)4.44

Net Charge (pH 7.0)-2.49

Net Charge (pH 7.4) -2.72

Charge Density (pH 7.0) -0.0396

GRAVY Index0.59

Hydrophobic Moment 0.51

Boman Index0.32

Instability Index19.93

Aliphatic Index 120.95

Aromaticity 0.0635

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2416.87

LogP -18.85

H-bond Donors 75.0

H-bond Acceptors 82.0

Rotatable Bonds 198.0

Heavy Atoms 457.0

Ring Count 12.0

Amide Bonds 68.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0231869 VERIFIED: YES

Provenance & Taxonomy

OrganismEumenes pomiformis [Animal]

FamilyMCD; Mastoparan subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic

TargetGram Negative Bacteria and Gram Positive Bacteria