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MYP_123757
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Basic Information
Diketopiperazine (preWF)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
2 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XF
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0170823 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
X=Prenylated-Trp
Bio-Activity Profile
Antimicrobial Anticancer
A2780-cisR
81.6 μM
IC50
PMID22617493 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22617493/
RECORD: Rec_0174734 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
tert-Butyloxycarbonyl
Methyl ester
Ornithine (Z)
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiviral Anticancer Antimalarial Antiparasitic
Plasmodium berghei ANKA 2.34
>200 μM
IC50; Microscopy
PMID23084276 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23084276/
RECORD: Rec_0174975 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Boc-Orn(Z)=tert-Butyloxycarbonyl
Methyl ester
Z=Ornithine
Bio-Activity Profile
Anticancer Antibacterial Antiviral Antiparasitic Antimicrobial Antifungal Antiplasmodial
PaperParaPep: a web resource for experimentally validated antiparasitic peptide sequences and their structures PMID24923818 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24923818/
RECORD: Rec_0217057 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide; DSSP H 0.0%, E 0.0%, T 0.0%, C 100.0% [Cyclic]
residue-level stereochemical modification [Mixed]
None
None
Sar
Bio-Activity Profile
Anticancer Antibacterial Antiviral Antiparasitic Antimicrobial Antifungal Antiplasmodial
PaperParaPep: a web resource for experimentally validated antiparasitic peptide sequences and their structures PMID24923818 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24923818/
RECORD: Rec_0244852 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Boc-Orn(Z)=tert-Butyloxycarbonyl
OtBu
Z=Ornithine
Bio-Activity Profile
Anticancer Antibacterial Antiviral Antiparasitic Antimicrobial Antifungal Antiplasmodial
PaperParaPep: a web resource for experimentally validated antiparasitic peptide sequences and their structures PMID24923818 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24923818/
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