‹ ›
MYP_123755
← PREVIOUS NEXT → BACK
Basic Information
SR9EK13
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition
Standard
35 amino acids
C171H293N45O59
Standard
Sequence
ISGINASVVNIQEEIKKLNEEAKKLNESLIDLQEL
Physicochemical Analysis
3923.42 Da
4.55
-3.23
-3.45
-0.0922
-0.30
0.70
-0.02
62.52
133.71
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1737.13
-16.49
56.0
56.0
144.0
275.0
0.0
40.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0077770 VERIFIED: YES
Provenance & Taxonomy
Severe acute respiratory syndrome-related coronavirus [Virus]
HR2-derived fusion inhibitor
694009
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Severe acute respiratory syndrome coronavirus
0.004 μM
EC50
PaperHeptad repeat-derived peptides block protease-mediated direct entry from the cell surface of severe acute respiratory syndrome coronavirus but not entry via the endosomal pathway PMID17942557 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17942557/
RECORD: Rec_0235168 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 48.6%, E 0.0%, T 5.7%, C 45.7% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0359227 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
SARS-CoV
PMID17942557 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17942557/
RECORD: Rec_0380307 VERIFIED: YES
Provenance & Taxonomy
Severe acute respiratory syndrome-related coronavirus [Virus]
Virus-derived peptide
694009;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor Fusion inhibitor Protease inhibitor
SARS coronavirus (Virus entry); Vero E6
0.004 μM
ELISA
PaperHeptad repeat-derived peptides block protease-mediated direct entry from the cell surface of severe acute respiratory syndrome coronavirus but not entry via the endosomal pathway. | Ujike M, Nishikawa H, Otaka A, Yamamoto N, Yamamoto N, Matsuoka M, Kodama E, Fujii N, Taguchi F. | J Virol. 2008 | PMID:17942557 PMID17942557 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17942557/