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MYP_123754
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Basic Information
Ligatoxin-B
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
46 amino acids
C194H319N63O67S6
Standard
Sequence
KSCCPSTTARNIYNTCRLTGASRSVCASLSGCKIISGSTCDSGWNH
Physicochemical Analysis
4798.38 Da
8.94
3.79
3.44
0.0823
-0.19
0.64
-0.04
57.57
55.22
0.0435
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2116.26
-34.61
84.0
78.0
155.0
330.0
5.0
48.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0053704 VERIFIED: YES
Provenance & Taxonomy
Phoradendron liga [Plant]
Thionin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Anticancer Cytotoxic Toxin
Human histiocytic lymphoma U-937/GTB
1.8 μM
IC50
PaperPubMed PMID 12049612 | PubMed PMID 25815330 PMID12049612;25815330 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12049612/
RECORD: Rec_0091688 VERIFIED: NO
Provenance & Taxonomy
Phoradendron liga [Plant]
Thionin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperLigatoxin-B Evidence URLhttps://www.uniprot.org/uniprotkb/P59358/entry
RECORD: Rec_0092472 VERIFIED: YES
Provenance & Taxonomy
Phoradendron liga [Plant]
Thionin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Anticancer Cytotoxic Toxin
Human renal adenocarcinoma ACHN
3.2 μM
IC50
PaperPubMed PMID 12049612 | PubMed PMID 25815330 PMID12049612;25815330 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12049612/
RECORD: Rec_0193710 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
PaperPhytAMP: a database dedicated to antimicrobial plant peptides PMID18836196 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18836196/
RECORD: Rec_0212724 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
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