Peptide Database

Peptide NameSLAY-screened peptide P1764

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC95H160N28O32S

DescriptionStandard

        HTILSSIAADDMVIRANTPVN
    

Molecular Weight2238.52 Da

Isoelectric Point (pI)5.21

Net Charge (pH 7.0)-1.15

Net Charge (pH 7.4) -1.41

Charge Density (pH 7.0) -0.0548

GRAVY Index0.32

Hydrophobic Moment 0.42

Boman Index0.15

Instability Index25.36

Aliphatic Index 116.19

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 968.81

LogP -11.41

H-bond Donors 33.0

H-bond Acceptors 33.0

Rotatable Bonds 71.0

Heavy Atoms 156.0

Ring Count 2.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0143415 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/