Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length411 amino acids

Chemical FormulaC2124H3393N543O599S14

DescriptionStandard

        MRFWWVFILLSLFLFQLEANPEVRIRITQRGLNYAKEIGMKLLEQELKARIFPDEIGTEKYFFGTVDYTVSRIQIMSISVYNSSVILIPENGIRLLLKNISVTVTTHWTFNNWLIDYQGEVEISILGLSITTDMIVALNNIGDLLVSIQNCQVSTGKIEVQLNSEGRWFYNAFVQHLEKVIHTRLESQLCLNVILRIQKETEVLKGLKDIKDSGSGAVFISGVNITAILSSYFNLTTDALESIIPTITHIYAKPLPVIMNIRIIDAPVVSLHDNKCILEFSASMEVLAKMPNSTTESMFTLNITTRTHADLFIFNRKLLTTLCLSSFHISLVHSNVGLFEASLLDNFLSYILRTGIIPAANFKLKDEFPLSVLDPVILMKPSIRMYEGFLLISSDIQSLRKRGTSRSPSKH
    

Molecular Weight46568.85 Da

Isoelectric Point (pI)7.12

Net Charge (pH 7.0)0.30

Net Charge (pH 7.4) -0.53

Charge Density (pH 7.0) 0.0007

GRAVY Index0.26

Hydrophobic Moment 0.71

Boman Index0.16

Instability Index40.77

Aliphatic Index 117.83

Aromaticity 0.0900

Extinction Coeff. Reduced 42400.00

Extinction Coeff. Oxidized 42650.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0067776 VERIFIED: NO

Provenance & Taxonomy

OrganismThamnophis sirtalis [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria