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MYP_123497
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Basic Information
PhD2 (PhD-2; Defensin-2; primates, mammals, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Standard
32 amino acids
C161H270N58O36S6
Standard
Sequence
RICRCRIGRCLGLEVYFGVCFLHGRLARRCCR
Physicochemical Analysis
3786.62 Da
9.98
6.79
6.45
0.2122
0.29
0.80
-0.17
28.01
94.38
0.0938
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1546.83
-13.49
66.0
50.0
126.0
261.0
4.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0106689 VERIFIED: YES
Provenance & Taxonomy
Papio hamadryas [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Listeria monocytogenes
2.1 μM
MIC
Paperalpha-Defensins from blood leukocytes of the monkey Papio hamadryas
RECORD: Rec_0163111 VERIFIED: YES
Provenance & Taxonomy
Papio hamadryas [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0175578 VERIFIED: YES
Provenance & Taxonomy
Papio hamadryas [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans
PMID16978151 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16978151/
RECORD: Rec_0179370 VERIFIED: YES
Provenance & Taxonomy
Papio hamadryas [Animal]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli
PaperPubMed PMID: 16978151 PMID16978151 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16978151/
RECORD: Rec_0190245 VERIFIED: YES
Provenance & Taxonomy
Papio hamadryas [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
PMID16978151 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16978151/
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