Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length390 amino acids

Chemical FormulaC1929H2997N481O539S14

DescriptionStandard

        MLACVLIALAFISCDCGKNPAIQVILTNKGLQSGRHVAAGWIQEKLDHVTLPDISGEIRVGFLLHIGYKLTGITIIKSDFPEPSVEFYQGFSGLKTSIEGLNVALTGSWEAHCGFVHGGGSFDMALFGVDVVSIVQLGRDAGGRLSLTSVNCNAQLGDLNTHFYVNFQVNQDLTLDLPLIGPPVVSASSLQLGLKGQFYSVKCPKEPPFVAMPFATPEQPAYMLSVGLSDFTVNSASFSYFSADLLQAFINDSMIPPSSPVRLNTTSLGPFIPQLPKMFPDLLMTLQIYATNFPVFSFRSGAVVLSSSGAVKAFAIQRNATLTPLFKLHVVSARFFVAFTGIKVLLLKLATGFALPHTKHAQLVNPVLTVEEGFVAFNSDAMLLEDTIFN
    

Molecular Weight41999.24 Da

Isoelectric Point (pI)6.12

Net Charge (pH 7.0)-3.75

Net Charge (pH 7.4) -4.57

Charge Density (pH 7.0) -0.0096

GRAVY Index0.42

Hydrophobic Moment 0.61

Boman Index0.26

Instability Index38.45

Aliphatic Index 103.23

Aromaticity 0.1026

Extinction Coeff. Reduced 21430.00

Extinction Coeff. Oxidized 21805.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0380981 VERIFIED: NO

Provenance & Taxonomy

OrganismHippocampus comes [Bacterium]

FamilyBPI

Tax ID109280

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence