Peptide Database

Peptide NameBrevinin-1AUb (Frogs, amphibians, animals)

Function Ontology

Anticancer

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Venom / Toxin ▸ General toxin ▸ Toxic

Standard StatusStandard

Sequence Length24 amino acids

Chemical FormulaC121H202N28O28S2

DescriptionStandard

        FLPILAGLAANILPKVFCSITKKC
    

Molecular Weight2561.20 Da

Isoelectric Point (pI)9.39

Net Charge (pH 7.0)2.74

Net Charge (pH 7.4) 2.50

Charge Density (pH 7.0) 0.1141

GRAVY Index1.19

Hydrophobic Moment 0.59

Boman Index0.40

Instability Index56.45

Aliphatic Index 138.33

Aromaticity 0.0833

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 876.65

LogP -3.79

H-bond Donors 31.0

H-bond Acceptors 33.0

Rotatable Bonds 82.0

Heavy Atoms 179.0

Ring Count 4.0

Amide Bonds 24.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0271349 VERIFIED: YES

Provenance & Taxonomy

OrganismRana aurora [Animal]

FamilyBrevinin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermCyclization

Disulfide18-24

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

RECORD: Rec_0279093 VERIFIED: YES

Provenance & Taxonomy

OrganismRana aurora aurora [Animal]

FamilyBrevinin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide18-24

Bio-Activity Profile

Function

Antimicrobial Antifungal

TargetStaphylococcus aureus

Activity3 μM

MethodMIC

RECORD: Rec_0324043 VERIFIED: YES

Provenance & Taxonomy

OrganismRana aurora [Animal]

FamilyBrevinin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermCyclization

Disulfide18-24

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetProteus mirabilis

Activity50 μM

MethodMIC

RECORD: Rec_0351840 VERIFIED: YES

Provenance & Taxonomy

OrganismRana aurora [Animal]

FamilyBrevinin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermCyclization

Disulfide18-24

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic

RECORD: Rec_0352723 VERIFIED: YES

Provenance & Taxonomy

OrganismRana aurora aurora [Animal]

FamilyBrevinin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetEnterococcus faecalis ATCC 29212

Activity6 μM

MethodMIC

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