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MYP_123426
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Basic Information
Brevinin-1AUb (Frogs, amphibians, animals)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
24 amino acids
C121H202N28O28S2
Standard
Sequence
FLPILAGLAANILPKVFCSITKKC
Physicochemical Analysis
2561.20 Da
9.39
2.74
2.50
0.1141
1.19
0.59
0.40
56.45
138.33
0.0833
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
876.65
-3.79
31.0
33.0
82.0
179.0
4.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0135192 VERIFIED: YES
Provenance & Taxonomy
Rana aurora aurora [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Enterobacter cloacae NHTCC 53001
25 μM
MIC
PMID15325526 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15325526/
RECORD: Rec_0161457 VERIFIED: YES
Provenance & Taxonomy
Rana aurora [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
25.0 μM
MIC
PaperJ.M. Conlon et al. / Developmental and Comparative Immunology 29 (2005) 83-90. Host-defense peptides isolated from the skin secretions of the Northern red-legged frog Rana aurora aurora
RECORD: Rec_0169437 VERIFIED: YES
Provenance & Taxonomy
Rana aurora [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Streptococcus Group B
13 μM
MIC
PMID15325526 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15325526/
RECORD: Rec_0185433 VERIFIED: YES
Provenance & Taxonomy
Rana aurora aurora [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Human erythrocytes
7 μM
HC50
PMID15325526 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15325526/
RECORD: Rec_0188661 VERIFIED: YES
Provenance & Taxonomy
Rana aurora [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus epidermidis
6 μM
MIC
PMID15325526 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15325526/
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