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MYP_123426
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Basic Information
Brevinin-1AUb (Frogs, amphibians, animals)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
24 amino acids
C121H202N28O28S2
Standard
Sequence
FLPILAGLAANILPKVFCSITKKC
Physicochemical Analysis
2561.20 Da
9.39
2.74
2.50
0.1141
1.19
0.59
0.40
56.45
138.33
0.0833
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
876.65
-3.79
31.0
33.0
82.0
179.0
4.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0111299 VERIFIED: YES
Provenance & Taxonomy
Rana aurora [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
3.0 μM
MIC
PaperJ.M. Conlon et al. / Developmental and Comparative Immunology 29 (2005) 83-90. Host-defense peptides isolated from the skin secretions of the Northern red-legged frog Rana aurora aurora
RECORD: Rec_0115578 VERIFIED: YES
Provenance & Taxonomy
Rana aurora aurora [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans ATCC 90028
3 μM
MIC
PMID15325526 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15325526/
RECORD: Rec_0117250 VERIFIED: YES
Provenance & Taxonomy
Rana aurora [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
human erythrocytes
7 μM
HC50
PMID15325526 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15325526/
RECORD: Rec_0131688 VERIFIED: YES
Provenance & Taxonomy
Rana aurora aurora [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Klebsiella pneumoniae KK3 9904
50 μM
MIC
PMID15325526 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15325526/
RECORD: Rec_0132987 VERIFIED: YES
Provenance & Taxonomy
Rana aurora [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida albicans
3 μM
MIC
PMID15325526 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15325526/
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