Peptide Database

Peptide NamesHR2-4(derived from SARS-CoV spike protein heptad repeat)

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Standard StatusStandard

Sequence Length52 amino acids

Chemical FormulaC252H409N69O87

DescriptionStandard

        FKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYE
    

Molecular Weight5797.35 Da

Isoelectric Point (pI)4.55

Net Charge (pH 7.0)-5.13

Net Charge (pH 7.4) -5.41

Charge Density (pH 7.0) -0.0987

GRAVY Index-0.50

Hydrophobic Moment 0.70

Boman Index-0.05

Instability Index29.24

Aliphatic Index 108.65

Aromaticity 0.0385

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2572.39

LogP -27.54

H-bond Donors 84.0

H-bond Acceptors 83.0

Rotatable Bonds 202.0

Heavy Atoms 408.0

Ring Count 4.0

Amide Bonds 59.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0058395 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetSARS-CoV; Vero cells

Activity50 μM

MethodEC50 (virus infection inhibition)

RECORD: Rec_0131475 VERIFIED: YES

Provenance & Taxonomy

OrganismSevere acute respiratory syndrome-related coronavirus [Virus]

FamilyVirus-derived peptide

Tax ID694009;0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Fusion inhibitor

TargetSARS-CoV

Activity>50 μM

MethodEC50

PaperSevere acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides. | Bosch BJ, Martina BE, Van Der Zee R, Lepault J, Haijema BJ, Versluis C, Heck AJ, De Groot R, Osterhaus AD, Rottier PJ. | Proc Natl Acad Sci U S A. 2004 | PMID:15150417 PMID15150417 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15150417/

RECORD: Rec_0166519 VERIFIED: NO

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

RECORD: Rec_0254064 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHR2 fusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-SARS-CoV Fusion inhibition

TargetSARS-CoV

Activity>50 μM

MethodEC50

Half-LifeMammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min

PaperSevere acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides. | Bosch BJ, Martina BE, Van Der Zee R, Lepault J, Haijema BJ, Versluis C, Heck AJ, De Groot R, Osterhaus AD, Rottier PJ. | Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8455-60. | DOI:10.1073/pnas.0400576101 | PMID:15150417 PMID15150417 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15150417/