Peptide Database

Peptide NameDermaseptin t-DPH1 [G1W,S4K,A11A,L18K]

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC107H178N30O23

DescriptionStandard

        WLWKKIKNVAKAAGKAAKGAL
    

Molecular Weight2252.75 Da

Isoelectric Point (pI)10.70

Net Charge (pH 7.0)5.75

Net Charge (pH 7.4) 5.54

Charge Density (pH 7.0) 0.2740

GRAVY Index-0.11

Hydrophobic Moment 0.68

Boman Index0.05

Instability Index6.46

Aliphatic Index 98.10

Aromaticity 0.0952

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 876.11

LogP -4.63

H-bond Donors 31.0

H-bond Acceptors 29.0

Rotatable Bonds 78.0

Heavy Atoms 160.0

Ring Count 4.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0375178 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDermaseptin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetEnterococcus faecalis NCTC 12697

Activity512 μM

MethodMIC

FIRST PREV 1 2 3

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