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MYP_123267
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Basic Information
Dermaseptin t-DPH1 [G1W,S4K,A11A,L18K]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
21 amino acids
C107H178N30O23
Standard
Sequence
WLWKKIKNVAKAAGKAAKGAL
Physicochemical Analysis
2252.75 Da
10.70
5.75
5.54
0.2740
-0.11
0.68
0.05
6.46
98.10
0.0952
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
876.11
-4.63
31.0
29.0
78.0
160.0
4.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0172025 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 8739
2 μM
MIC
PMID34943741 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34943741/
RECORD: Rec_0184097 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
PMID34943741 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34943741/
RECORD: Rec_0184376 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 6538
128 μM
MIC
PMID34943741 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34943741/
RECORD: Rec_0227403 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans ATCC 10231
512 μM
MIC
PMID34943741 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34943741/
RECORD: Rec_0292753 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Klebsiella pneumoniae ATCC 43816
64 μM
MIC
PMID34943741 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34943741/
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