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MYP_123176
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Basic Information
Wollamide B [V4A]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
6 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
WLLANX
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0107118 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
unspecified non-canonical residue at 6
Bio-Activity Profile
Antimicrobial Antibacterial
Bacillus cereus ATCC 14579
200 μg/mL
MIC
PMID29431987;28423019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29431987/
RECORD: Rec_0116578 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
unspecified non-canonical residue at 6
Bio-Activity Profile
Antimicrobial Antibacterial
Human hepatocellular carcinoma HepG2
100 μM
IC50
PMID29431987;28423019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29431987/
RECORD: Rec_0142518 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic designed peptide
32630
Structure & Mods
cyclic peptide [Cyclic]
all-D amino-acid peptide [D]
None
None
Third residue is D-leucine and x= ornithine
Bio-Activity Profile
Antimicrobial Antimycobacterial
Mycobacterium tuberculosis H37Rv
80 μM
MIC
PMID28423019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28423019/
RECORD: Rec_0351499 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
None
None
l=D-Leu; x(6)=D-Orn
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperPubMed PMID: 28423019 PMID28423019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28423019/
RECORD: Rec_0358565 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
unspecified non-canonical residue at 6
Bio-Activity Profile
Hemolytic
Vero cells (IC50 at 242.7 microg/ml
50 μg/mL
Hemolysis
PMID29431987;28423019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29431987/
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