Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length437 amino acids

Chemical FormulaC2149H3442N560O612S19

DescriptionStandard

        MTLCWWFLLVAFIPMTSGTNPGVKVKLTEKGLEYGRQLGMVSIQQKLKSIKVPDFSGSQTVSPIGNVKYSLSNMCIVSVGLPQSAVNLVQGTGMRLSVSNAFISLRGNWKVKYLHIIKDSGSFDLKVKGLTIGTSIAIKSDETGRPAVSNVNCGATVSSASVKFHGGASWLYNLFRKFIDKALRSAMQKQMCPLVTNAISDLNPQLKTLNVLAKVDQYAEIEYSMVSSPIVSNSSIDFSLKGEFYNIGKHQEPPFSPSAFTLPSQINNMLYIGMSAFTANSAAFVYNKAGALHLFVTDDMIPQSSPIRLNTRTFGAFIPQIAKRFPGLMMKLLVQTVKPPVTTFEPNNLTVQASSTVTAYAIQPNTTLSPLFVLNLETSVSAQVFVRGMRLAGAVTLNKMTLTLGTSYVGEFQVRSLDSILQLVLKVVVIPRLNAPP
    

Molecular Weight47524.94 Da

Isoelectric Point (pI)9.79

Net Charge (pH 7.0)18.81

Net Charge (pH 7.4) 18.25

Charge Density (pH 7.0) 0.0430

GRAVY Index0.19

Hydrophobic Moment 0.85

Boman Index0.16

Instability Index33.08

Aliphatic Index 98.10

Aromaticity 0.0847

Extinction Coeff. Reduced 38390.00

Extinction Coeff. Oxidized 38640.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0117898 VERIFIED: NO

Provenance & Taxonomy

OrganismLates calcarifer [Bacterium]

FamilyBPI

Tax ID8187

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence