Peptide Database

Peptide NameSLAY-screened peptide P3381

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length16 amino acids

Chemical FormulaC80H137N23O21S3

DescriptionStandard

        CHCTMITTHLTPLLLR
    

Molecular Weight1853.28 Da

Isoelectric Point (pI)8.09

Net Charge (pH 7.0)0.91

Net Charge (pH 7.4) 0.58

Charge Density (pH 7.0) 0.0572

GRAVY Index0.71

Hydrophobic Moment 0.40

Boman Index0.21

Instability Index62.16

Aliphatic Index 121.88

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 691.21

LogP -5.26

H-bond Donors 27.0

H-bond Acceptors 27.0

Rotatable Bonds 57.0

Heavy Atoms 127.0

Ring Count 3.0

Amide Bonds 15.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0191537 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/