Peptide Database

Peptide NameDenileukin diftitox

Function Ontology

Anticancer

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Therapeutic / Biomedical activity ▸ Enzyme replacement therapy

Standard StatusStandard

Sequence Length521 amino acids

Chemical FormulaC2560H4042N678O799S17

DescriptionStandard

        MGADDVVDSSKSFVMENFSSYHGTKPGYVDSIQKGIQKPKSGTQGNYDDDWKGFYSTDNKYDAAGYSVDNENPLSGKAGGVVKVTYPGLTKVLALKVDNAETIKKELGLSLTEPLMEQVGTEEFIKRFGDGASRVVLSLPFAEGSSSVEYINNWEQAKALSVELEINFETRGKRGQDAMYEYMAQACAGNRVRRSVGSSLSCINLDWDVIRDKTKTKIESLKEHGPIKNKMSESPNKTVSEEKAKQYLEEFHQTALEHPELSELKTVTGTNPVFAGANYAAWAVNVAQVIDSETADNLEKTTAALSILPGIGSVMGIADGAVHHNTEEIVAQSIALSSLMVAQAIPLVGELVDIGFAAYNFVESIINLFQVVHNSYNRPAYSPGHKTHAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT
    

Molecular Weight57646.65 Da

Isoelectric Point (pI)5.45

Net Charge (pH 7.0)-13.41

Net Charge (pH 7.4) -14.48

Charge Density (pH 7.0) -0.0257

GRAVY Index-0.30

Hydrophobic Moment 0.86

Boman Index0.03

Instability Index40.51

Aliphatic Index 86.47

Aromaticity 0.0787

Extinction Coeff. Reduced 54320.00

Extinction Coeff. Oxidized 54570.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0361136 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Escherichia coli [Bacterium]

FamilyInterleukin

Tax ID9606; 562

Structure & Mods

Configsingle-chain therapeutic peptide/protein [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsGlycosylation

Bio-Activity Profile

Function

Anticancer Immunomodulatory Enzyme replacement

Half-Life1.16-1.3 hours