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MYP_122891
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Basic Information
HTLV-1 gp (400-429)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Retrovirus ▸ Anti-HTLV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Standard
30 amino acids
C151H241N43O43S2
Standard
Sequence
CCFLNITNSHVSILQERPPLENRVLTGWGL
Physicochemical Analysis
3410.92 Da
6.74
-0.17
-0.45
-0.0056
0.10
0.38
0.11
53.68
110.33
0.0667
5500.00
5625.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1385.79
-12.95
49.0
46.0
108.0
239.0
6.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0367083 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
Human T cell leukemia virus type 1(HTLV-1):inhibition of mambrane fusion in 293T cells
0.18±0.01 μM
IC50
PaperPubMed PMID: 19114713 PMID19114713 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19114713/
RECORD: Rec_0376550 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 19114713 PMID19114713 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19114713/
RECORD: Rec_0380767 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0382199 VERIFIED: YES
Provenance & Taxonomy
Human T-lymphotropic virus 1 [Virus]
Virus-derived peptide
11908;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Fusion inhibitor
Human T-cell leukaemia virus 1 (Fusion); HeLa
0.28 μM
Syncytia assay
PaperHighly specific inhibition of leukaemia virus membrane fusion by interaction of peptide antagonists with a conserved region of the coiled coil of envelope. | Lamb D, Schuttelkopf AW, van Aalten DM, Brighty DW. | Retrovirology. 2008 | PMID:18680566 PMID18680566 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18680566/
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