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MYP_122891
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Basic Information
HTLV-1 gp (400-429)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Retrovirus ▸ Anti-HTLV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Standard
30 amino acids
C151H241N43O43S2
Standard
Sequence
CCFLNITNSHVSILQERPPLENRVLTGWGL
Physicochemical Analysis
3410.92 Da
6.74
-0.17
-0.45
-0.0056
0.10
0.38
0.11
53.68
110.33
0.0667
5500.00
5625.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1385.79
-12.95
49.0
46.0
108.0
239.0
6.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0015430 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Human T-cell leukaemia virus 1 (HTLV-1)
PMID18680566 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18680566/
RECORD: Rec_0039146 VERIFIED: YES
Provenance & Taxonomy
Human T-lymphotropic virus 1 [Virus]
Virus-derived peptide
11908;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Human T-cell leukaemia virus 1 (Virus entry); MT2
0.28 μM
Syncytia assay
PaperAn antiviral peptide targets a coiled-coil domain of the human T-cell leukemia virus envelope glycoprotein. | Pinon JD, Kelly SM, Price NC, Flanagan JU, Brighty DW. | J Virol. 2003 | PMID:12584351 PMID12584351 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12584351/
RECORD: Rec_0132669 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Bovine leukaemia virus
PMID18680566 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18680566/
RECORD: Rec_0204041 VERIFIED: YES
Provenance & Taxonomy
Human T-lymphotropic virus 1 [Virus]
Virus-derived peptide
11908;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Human T-cell leukaemia virus 1 (Virus entry); 293T
0.18 μM
Luciferase assay
PaperBasic residues are critical to the activity of peptide inhibitors of human T cell leukemia virus type 1 entry. | Lamb D, Mirsaliotis A, Kelly SM, Brighty DW. | J Biol Chem. 2009 | PMID:19114713 PMID19114713 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19114713/
RECORD: Rec_0230367 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-HTLV Fusion inhibition
HTLV | T cell; 293T cells
0.18±0.01 μM
IC50
Mammalian: 1.2 h; Yeast: >20 h; E. coli: >10 h
PaperBasic residues are critical to the activity of peptide inhibitors of human T cell leukemia virus type 1 entry. | Lamb D, Mirsaliotis A, Kelly SM, Brighty DW. | J Biol Chem. 2009 Mar 6;284(10):6575-84. | DOI:10.1074/jbc.M806725200 | PMID:19114713 PMID19114713 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19114713/
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