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MYP_122869
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Basic Information
Mucroporin-M1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza A ▸ Anti-H5N1
Antiviral ▸ Antiviral mechanism ▸ Pseudovirus inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Antiviral ▸ Virucidal activity
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
17 amino acids
C98H170N26O20
Standard
Sequence
LFRLIKSLIKRLVSAFK
Physicochemical Analysis
2032.56 Da
12.00
4.76
4.55
0.2798
0.79
0.88
0.07
9.76
160.59
0.1176
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
771.24
-2.51
29.0
25.0
72.0
144.0
2.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0214497 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
measles virus (MeV):inhibition of MeV infection in Vero cells
7.15 μg/mL
EC50
PaperPubMed PMID: 21620914 PMID21620914 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21620914/
RECORD: Rec_0232888 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-SARS-CoV Pseudovirus inhibition
SARS-CoV (pseudovirus) | MDCK cells
7.12 μM
EC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperVirucidal activity of a scorpion venom peptide variant mucroporin-M1 against measles, SARS-CoV and influenza H5N1 viruses. | Li Q, Zhao Z, Zhou D, Chen Y, Hong W, Cao L, Yang J, Zhang Y, Shi W, Cao Z, Wu Y, Yan H, Li W. | Peptides. 2011 Jul;32(7):1518-25. | DOI:10.1016/j.peptides.2011.05.015 | PMID:21620914 PMID21620914 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21620914/
RECORD: Rec_0251114 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Enterococcus faecium [Synthetic]
Bacteriocin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral
measles McV
7.15 μg/mL
EC50
PaperBacteriocin T8, a novel class IIa sec-dependent bacteriocin produced by Enterococcus faecium T8, isolated from vaginal secretions of children infected with human immunodeficiency virus.
RECORD: Rec_0258229 VERIFIED: YES
Provenance & Taxonomy
Lychas mucronatus [Animal]
Scorpion venom peptide
172552
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Severe acute respiratory syndrome coronavirus
7.12 μg/mL
EC50
PaperVirucidal activity of a scorpion venom peptide variant mucroporin-M1 against measles, SARS-CoV and influenza H5N1 viruses PMID21620914 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21620914/
RECORD: Rec_0260692 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Enterococcus faecium [Synthetic]
Bacteriocin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral
Bacillus subtilis AB91021
25 μg/mL
MIC
PaperBacteriocin T8, a novel class IIa sec-dependent bacteriocin produced by Enterococcus faecium T8, isolated from vaginal secretions of children infected with human immunodeficiency virus.
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