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MYP_122869
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Basic Information
Mucroporin-M1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza A ▸ Anti-H5N1
Antiviral ▸ Antiviral mechanism ▸ Pseudovirus inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Antiviral ▸ Virucidal activity
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
17 amino acids
C98H170N26O20
Standard
Sequence
LFRLIKSLIKRLVSAFK
Physicochemical Analysis
2032.56 Da
12.00
4.76
4.55
0.2798
0.79
0.88
0.07
9.76
160.59
0.1176
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
771.24
-2.51
29.0
25.0
72.0
144.0
2.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0115771 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-H5N1 Pseudovirus inhibition
H5N1 (pseudovirus) | MDCK cells
1.03 μM
EC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperVirucidal activity of a scorpion venom peptide variant mucroporin-M1 against measles, SARS-CoV and influenza H5N1 viruses. | Li Q, Zhao Z, Zhou D, Chen Y, Hong W, Cao L, Yang J, Zhang Y, Shi W, Cao Z, Wu Y, Yan H, Li W. | Peptides. 2011 Jul;32(7):1518-25. | DOI:10.1016/j.peptides.2011.05.015 | PMID:21620914 PMID21620914 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21620914/
RECORD: Rec_0169739 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
H5N1(pseudovirus):inhibition of H5N1 infection in MDCK cells
2.10 μg/mL
EC50
PaperPubMed PMID: 21620914 PMID21620914 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21620914/
RECORD: Rec_0173221 VERIFIED: NO
Provenance & Taxonomy
Lychas mucronatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral
RECORD: Rec_0182413 VERIFIED: YES
Provenance & Taxonomy
Scorpiones [Animal]
Scorpion venom peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Virucidal Replication inhibitor
Influenza A virus (Replication); MDCK
Plaque assay
PaperVirucidal activity of a scorpion venom peptide variant mucroporin-M1 against measles, SARS-CoV and influenza H5N1 viruses. | Li Q, Zhao Z, Zhou D, Chen Y, Hong W, Cao L, Yang J, Zhang Y, Shi W, Cao Z, Wu Y, Yan H, Li W. | Peptides. 2011 | PMID:21620914 PMID21620914 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21620914/
RECORD: Rec_0186148 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Enterococcus faecium [Synthetic]
Bacteriocin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral
Pseudomonas aeruginosa AB93066
100 μg/mL
MIC
PaperBacteriocin T8, a novel class IIa sec-dependent bacteriocin produced by Enterococcus faecium T8, isolated from vaginal secretions of children infected with human immunodeficiency virus.
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