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MYP_122869
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Basic Information
Mucroporin-M1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza A ▸ Anti-H5N1
Antiviral ▸ Antiviral mechanism ▸ Pseudovirus inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Antiviral ▸ Virucidal activity
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
17 amino acids
C98H170N26O20
Standard
Sequence
LFRLIKSLIKRLVSAFK
Physicochemical Analysis
2032.56 Da
12.00
4.76
4.55
0.2798
0.79
0.88
0.07
9.76
160.59
0.1176
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
771.24
-2.51
29.0
25.0
72.0
144.0
2.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0000173 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Enterococcus faecium [Synthetic]
Bacteriocin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral
Escherichia coli AB94012
12.5 μg/mL
MIC
PaperBacteriocin T8, a novel class IIa sec-dependent bacteriocin produced by Enterococcus faecium T8, isolated from vaginal secretions of children infected with human immunodeficiency virus.
RECORD: Rec_0016882 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 82.4%, E 5.9%, T 0.0%, C 11.8% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0031708 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
H5N1
2.10 μg/mL
EC50
PMID26492266;21620914 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26492266/
RECORD: Rec_0033803 VERIFIED: YES
Provenance & Taxonomy
Scorpiones [Animal]
Scorpion venom peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Virucidal Replication inhibitor
SARS coronavirus (Replication); MDCK
Plaque assay
PaperVirucidal activity of a scorpion venom peptide variant mucroporin-M1 against measles, SARS-CoV and influenza H5N1 viruses. | Li Q, Zhao Z, Zhou D, Chen Y, Hong W, Cao L, Yang J, Zhang Y, Shi W, Cao Z, Wu Y, Yan H, Li W. | Peptides. 2011 | PMID:21620914 PMID21620914 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21620914/
RECORD: Rec_0063390 VERIFIED: YES
Provenance & Taxonomy
Scorpiones [Animal]
Scorpion venom peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Replication inhibitor
Hepatitis B virus (Replication); HepG2.2.15
11 μM
RT-PCR
PaperMucroporin-M1 inhibits hepatitis B virus replication by activating the mitogen-activated protein kinase (MAPK) pathway and down-regulating HNF4α in vitro and in vivo. | Zhao Z, Hong W, Zeng Z, Wu Y, Hu K, Tian X, Li W, Cao Z. | J Biol Chem. 2012 | PMID:22791717 PMID22791717 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22791717/
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