Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length440 amino acids

Chemical FormulaC2216H3535N559O646S20

DescriptionStandard

        MKSCVVIFFLVSLISSDTAAPPPGIKVRITEKVKDLGLMYLKGLVNKQFPIDDICLPIKSVNLTDLQVDPAKVDFKFQENIGVQIEIKDMNFSLEIQREAKVPFTQIKIIEGTTTLTAEGVTATITVRMNQNPQGHLNVEIPRDNCTIKADTIRTTSSGLTGFLLDSLQYFRLYLYLFNDKICPALQPMINNKLKDLPMMSTVYEDHQLDLDYSLSSDIEVTSSSLDISFKGLLSVHGKAVDPGSIRPGREPVFTETNKMVYVGISEFFFNGAAMAIYKSGPFEFNVPEMEGLLVGLGQKIMEIKPGPWTAELIEAPIIEISNDDLSATAYFKAQRKAKLNGFLMTCRFKMDIEFKERLLIMNIQEPKCKEKAGKIKGKFLAFLVNVFHERITKSLVKEIPIPLPAELSLINATNQFEEGYLVVGGSLTFNPQNSSNAGG
    

Molecular Weight48985.43 Da

Isoelectric Point (pI)5.80

Net Charge (pH 7.0)-4.15

Net Charge (pH 7.4) -4.79

Charge Density (pH 7.0) -0.0094

GRAVY Index-0.01

Hydrophobic Moment 0.75

Boman Index0.10

Instability Index31.43

Aliphatic Index 98.14

Aromaticity 0.0841

Extinction Coeff. Reduced 20400.00

Extinction Coeff. Oxidized 20775.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0331457 VERIFIED: NO

Provenance & Taxonomy

OrganismOreochromis niloticus (Not founde tilapia) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria