Peptide Database

Peptide NameSLAY-screened peptide P5366

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC112H157N23O29

DescriptionStandard

        PIPSPSWITYPVYVLAYDAH
    

Molecular Weight2289.58 Da

Isoelectric Point (pI)5.08

Net Charge (pH 7.0)-0.96

Net Charge (pH 7.4) -1.07

Charge Density (pH 7.0) -0.0478

GRAVY Index0.23

Hydrophobic Moment 0.25

Boman Index0.38

Instability Index68.92

Aliphatic Index 97.50

Aromaticity 0.2000

Extinction Coeff. Reduced 9970.00

Extinction Coeff. Oxidized 9970.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 779.01

LogP -2.58

H-bond Donors 27.0

H-bond Acceptors 29.0

Rotatable Bonds 59.0

Heavy Atoms 164.0

Ring Count 10.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0327988 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Familyp53-derived

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/