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MYP_122617
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Basic Information
I-4
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
15 amino acids
C94H159N39O17
Standard
Sequence
VRRFRRFFRRLRRSV
Physicochemical Analysis
2107.52 Da
12.00
7.73
7.52
0.5156
-1.08
1.19
-0.91
204.21
64.67
0.2000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
986.15
-8.63
41.0
25.0
72.0
150.0
3.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0178708 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Human breast adenocarcinoma MCF-7
16.9
IC50
PMID28664269 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28664269/
RECORD: Rec_0222717 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Human cervical carcinoma HeLa
10.7
IC50
PMID28664269 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28664269/
RECORD: Rec_0326162 VERIFIED: YES
Provenance & Taxonomy
cationic host defense peptides [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Rabbit red blood cells: modest hemolytic activity(as show in Fig.2)
PaperPro-apoptotic cationic host defense peptides rich in lysine or arginine to reverse drug resistance by disrupting tumor cell membrane. Amino Acids. 2017 Sep;49(9):1601-1610. doi: 10.1007/s00726-017-2453-y. PMID: 28664269. PMID28664269 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28664269/
RECORD: Rec_0339277 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Human breast adenocarcinoma MCF-7/Taxol
40.6
IC50
PMID28664269 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28664269/
RECORD: Rec_0341797 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Human umbilical vein endothelial cells HUVEC
69.74±2.9 μM
IC50
PMID28664269 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28664269/
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