Peptide Database

Peptide NameI-4

Function Ontology

Anticancer

Antimicrobial

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC94H159N39O17

DescriptionStandard

        VRRFRRFFRRLRRSV
    

Molecular Weight2107.52 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)7.73

Net Charge (pH 7.4) 7.52

Charge Density (pH 7.0) 0.5156

GRAVY Index-1.08

Hydrophobic Moment 1.19

Boman Index-0.91

Instability Index204.21

Aliphatic Index 64.67

Aromaticity 0.2000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 986.15

LogP -8.63

H-bond Donors 41.0

H-bond Acceptors 25.0

Rotatable Bonds 72.0

Heavy Atoms 150.0

Ring Count 3.0

Amide Bonds 14.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0178708 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Familycathelicidin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Anticancer Cytotoxic Pro-apoptotic

TargetHuman breast adenocarcinoma MCF-7

Activity16.9 μM

MethodIC50

RECORD: Rec_0222717 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Familycathelicidin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Anticancer Cytotoxic Pro-apoptotic

TargetHuman cervical carcinoma HeLa

Activity10.7 μM

MethodIC50

RECORD: Rec_0326162 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Hemolysis-tested Low hemolytic

TargetRabbit erythrocytes

MethodHemolysis

PaperPro-apoptotic cationic host defense peptides rich in lysine or arginine to reverse drug resistance by disrupting tumor cell membrane. Amino Acids. 2017 Sep;49(9):1601-1610. doi: 10.1007/s00726-017-2453-y. PMID: 28664269. PMID28664269 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28664269/

RECORD: Rec_0339277 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Familycathelicidin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Anticancer Cytotoxic Pro-apoptotic

TargetHuman breast adenocarcinoma MCF-7/Taxol

Activity40.6 μM

MethodIC50

RECORD: Rec_0341797 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Familycathelicidin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Cytotoxicity Selectivity assessment

TargetHuman umbilical vein endothelial cells HUVEC

Activity69.74±2.9 μM

MethodIC50

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