Peptide Database

Peptide NamePYLa PGLa B [Cleaved into: PYLa; PGLa; PGLa-H]

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive ▸ Anti-Staphylococcus aureus

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Standard StatusStandard

Sequence Length64 amino acids

Chemical FormulaC294H495N83O88S5

DescriptionStandard

        MYKQIFLCLIIAALCATIMAEASALADADDDDDKRYVRGMASKAGAIAGKIAKVALKALGRRDS
    

Molecular Weight6760.90 Da

Isoelectric Point (pI)8.68

Net Charge (pH 7.0)1.48

Net Charge (pH 7.4) 1.22

Charge Density (pH 7.0) 0.0232

GRAVY Index0.29

Hydrophobic Moment 0.62

Boman Index0.07

Instability Index28.04

Aliphatic Index 105.62

Aromaticity 0.0469

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3105.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2763.21

LogP -25.47

H-bond Donors 100.0

H-bond Acceptors 95.0

Rotatable Bonds 234.0

Heavy Atoms 470.0

Ring Count 3.0

Amide Bonds 64.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0246820 VERIFIED: YES

Provenance & Taxonomy

OrganismXenopus laevis [Animal]

FamilyMagainin

Tax ID8355

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal Anti-MRSA Anti-Candida Anti-Gram-positive Cytolytic Hemolytic

TargetCandida albicans

RECORD: Rec_0358720 VERIFIED: YES