Peptide Database

Peptide NameBig defensin

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length117 amino acids

Chemical FormulaC582H916N166O160S9

DescriptionStandard

        MKGNIGIAVFYMLLLLLPTDSIGKKMEEEQEKLFRQKRNPLIPAIYIGATVGPSVWAYLVALVGAAAVTAANIRRASSDNHSCAGNRGWCRSKCFRHEYVDTYYSAVCGRYFCCRSR
    

Molecular Weight13087.10 Da

Isoelectric Point (pI)9.41

Net Charge (pH 7.0)7.62

Net Charge (pH 7.4) 7.19

Charge Density (pH 7.0) 0.0651

GRAVY Index-0.02

Hydrophobic Moment 0.58

Boman Index0.03

Instability Index56.23

Aliphatic Index 84.27

Aromaticity 0.1111

Extinction Coeff. Reduced 21430.00

Extinction Coeff. Oxidized 21805.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5252.22

LogP -49.06

H-bond Donors 194.0

H-bond Acceptors 179.0

Rotatable Bonds 427.0

Heavy Atoms 917.0

Ring Count 21.0

Amide Bonds 123.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0175530 VERIFIED: YES

Provenance & Taxonomy

OrganismTachypleus tridentatus [Animal]

FamilyDefensin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Defensin Antifungal Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetGram Negative Bacteria and Gram Positive Bacteria