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MYP_122533
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Basic Information
Vpr-1 R8
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Standard
14 amino acids
C85H156N40O17
Standard
Sequence
LQQLLFRRRRRRRR
Physicochemical Analysis
2010.41 Da
12.00
7.76
7.56
0.5543
-2.06
0.39
-1.25
332.73
83.57
0.0714
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1023.00
-10.28
41.0
25.0
73.0
142.0
1.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0016347 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
PMID20586421 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20586421/
RECORD: Rec_0059559 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-HIV-1 Replication inhibition
HIV-1
6.1±1.1 μM
IC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperPeptide HIV-1 integrase inhibitors from HIV-1 gene products. | Suzuki S, Urano E, Hashimoto C, Tsutsumi H, Nakahara T, Tanaka T, Nakanishi Y, Maddali K, Han Y, Hamatake M, Miyauchi K, Pommier Y, Beutler JA, Sugiura W, Fuji H, Hoshino T, Itotani K, Nomura W, Narumi T, Yamamoto N, Komano JA, Tamamura H. | J Med Chem. 2010 Jul 22;53(14):5356-60. | DOI:10.1021/jm1003528 | PMID:20586421 PMID20586421 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20586421/
RECORD: Rec_0148457 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
inhibition of strand transfer catalyzed by integrase
11 μM
IC50
PMID20586421 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20586421/
RECORD: Rec_0284387 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:Inhibition of 3′-end processing catalyzed by integrase
6.1±1.1 μM
IC50
PMID20586421 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20586421/
RECORD: Rec_0410491 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Replication inhibition
inhibition of strand transfer catalyzed by integrase
11 μM
IC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperPeptide HIV-1 integrase inhibitors from HIV-1 gene products. | Suzuki S, Urano E, Hashimoto C, Tsutsumi H, Nakahara T, Tanaka T, Nakanishi Y, Maddali K, Han Y, Hamatake M, Miyauchi K, Pommier Y, Beutler JA, Sugiura W, Fuji H, Hoshino T, Itotani K, Nomura W, Narumi T, Yamamoto N, Komano JA, Tamamura H. | J Med Chem. 2010 Jul 22;53(14):5356-60. | DOI:10.1021/jm1003528 | PMID:20586421 PMID20586421 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20586421/