Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length274 amino acids

Chemical FormulaC1365H2105N347O393S15

DescriptionStandard

        MVEGVIHGWMDVWIVCIVCSAYVLLCYSCTVFAGKHESTGWIQEKLEQITFPDITGSVNIYIGRVYYTLSGVTIKKCDLPEPSVEFVQPGGLTTSIAGLSFAVAGEWRTRFCTIHDGGSFNMAIFNIDVTSTVQLGRDAGGHLSVTSVSCKASVGDLAIQFYGGASKIFQPFVKRFKGHIIGRIQNQICPEVENSIMNLDRHLQAMNVSFDVNEVLNFDVPLTGVPDVEPQNMKLGFKGEFQSIKTHKEPPFVAQEFILPELAGYMLSVGISEF
    

Molecular Weight30145.38 Da

Isoelectric Point (pI)5.35

Net Charge (pH 7.0)-7.93

Net Charge (pH 7.4) -8.68

Charge Density (pH 7.0) -0.0289

GRAVY Index0.20

Hydrophobic Moment 0.73

Boman Index0.20

Instability Index40.66

Aliphatic Index 92.74

Aromaticity 0.1058

Extinction Coeff. Reduced 32430.00

Extinction Coeff. Oxidized 32930.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0302652 VERIFIED: NO

Provenance & Taxonomy

OrganismPoeciliopsis prolifica [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria