Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length508 amino acids

Chemical FormulaC2582H4032N642O739S18

DescriptionStandard

        MCTKMAQVQVLWGCILLWNLYISSAQAIYPGIKARATQRALDYAVQAGMEMIEQMAKERKLPDLKGSESLEFLKIDYVNYNFTNIKINAFSFPNTSLAFVPGVGIRALTNHGTTNISTDWEVKSALFQDTGAADLFLSGVYFTGIVVLSRNDFGHPILKLQDCYAQVSHADVSFSGELSVLYNSFAEPMEKPILKKLNEMLCPIITGEVEALNANLSMLEVLRKIDNYTLLDYSLVSSPEITENYFDLNLKGVFYPLKSLQYPPFPSVPFVLPERSDSMLYVGISKYFFKSASYAYFTAGAFSFTLTTKEISNHLLHNSQALGNMLTRIAELYILSQPFMVQVTATEPPVISLLPGNFTLDIPASIMILTQPKNSTAETIVSMDFVASTNVALAILGQRLICSLSLNRFRLSLPESNRSNIEVLRFENILSSILHFGVLPLANAKLQQGFPLPNPHKISLVNSDIEVLEGFLLISTDLKYKTSKQQPGFLGWEGLHLISGQWSGKPTP
    

Molecular Weight56468.66 Da

Isoelectric Point (pI)5.96

Net Charge (pH 7.0)-4.80

Net Charge (pH 7.4) -5.62

Charge Density (pH 7.0) -0.0095

GRAVY Index0.14

Hydrophobic Moment 0.68

Boman Index0.17

Instability Index37.46

Aliphatic Index 102.89

Aromaticity 0.1043

Extinction Coeff. Reduced 55810.00

Extinction Coeff. Oxidized 56060.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0322469 VERIFIED: NO

Provenance & Taxonomy

OrganismCapra hircus [Animal]

FamilyBPI

Tax ID9925

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence