Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length474 amino acids

Chemical FormulaC2354H3678N594O693S24

DescriptionStandard

        MLPHMMVALTLMSLTCGETPAVQVILTNKGLQYGKDACAAWIQDRLELITFPDISGDIQISIFGSIDYTLTGTTITKCDFPDPSVEFYEDYTGFKTSISGLSVAVTGEIMAQWGIIKYSGSFNMAILGVDVTSVLELGKDADGRLSVTSVSCDARIEDVDIQLNGGFRPAVKIFSSEHCRIFTLFTPQICPTVKDSIVNLEYHLQAMNVSFDVNQDITVDLPLTNLSFISASSLNLGLKGEFYSTKMHTEPPFEPQPFMVPEQTGYMLSLGFSEFTLNSASFGYYSAGLLQLLVNDSMIPSLSPVRLNTSSMGSFIPQLPKMYPGLLMDLQVYARDIPLFSFRPGVVELDLQGAIKAFAIQSNGTHIPLFKLNADSKLSGKVWIADGRLKGSMGMNNFTLTLAASDVGPFKRDNDRLGKGIYLPRLKHAELVNTVLEVDTVSFNERHHINVSVWPAEENGIMWIKCVFLPNRAL
    

Molecular Weight52157.51 Da

Isoelectric Point (pI)5.03

Net Charge (pH 7.0)-13.82

Net Charge (pH 7.4) -14.64

Charge Density (pH 7.0) -0.0291

GRAVY Index0.14

Hydrophobic Moment 0.71

Boman Index0.17

Instability Index34.25

Aliphatic Index 96.43

Aromaticity 0.0949

Extinction Coeff. Reduced 46870.00

Extinction Coeff. Oxidized 47245.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0304161 VERIFIED: NO

Provenance & Taxonomy

OrganismMola mola [Bacterium]

FamilyBPI

Tax ID94237

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence