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MYP_122201
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Basic Information
FP
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Anti-Flavivirus ▸ Anti-Dengue virus
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
19 amino acids
C118H197N35O21S
Standard
Sequence
MGRFKRFRKKFKKLFKKLS
Physicochemical Analysis
2474.11 Da
12.00
9.49
9.27
0.4996
-1.12
0.82
-0.54
-6.04
41.05
0.2105
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
975.19
-4.74
37.0
32.0
93.0
175.0
4.0
18.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0255521 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
human red blood cells
500 μg/mL
Hemolysis
PMID30716944 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30716944/
RECORD: Rec_0385320 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HSV Infection inhibition
Herpes simplex virus 2; Huh7 cells
50 %
Virus infection inhibition at 10 μM
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperBomidin: An Optimized Antimicrobial Peptide With Broad Antiviral Activity Against Enveloped Viruses. | Liu R, Liu Z, Peng H, Lv Y, Feng Y, Kang J, Lu N, Ma R, Hou S, Sun W, Ying Q, Wang F, Gao Q, Zhao P, Zhu C, Wang Y, Wu X. | Front Immunol. 2022 May 19;13:851642. | DOI:10.3389/fimmu.2022.851642 | PMID:35663971 PMID35663971 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35663971/
RECORD: Rec_0391394 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Infection inhibition
SARS-CoV-2; Huh7 cells
80 %
Virus infection inhibition at 10 μM
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperBomidin: An Optimized Antimicrobial Peptide With Broad Antiviral Activity Against Enveloped Viruses. | Liu R, Liu Z, Peng H, Lv Y, Feng Y, Kang J, Lu N, Ma R, Hou S, Sun W, Ying Q, Wang F, Gao Q, Zhao P, Zhu C, Wang Y, Wu X. | Front Immunol. 2022 May 19;13:851642. | DOI:10.3389/fimmu.2022.851642 | PMID:35663971 PMID35663971 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35663971/
RECORD: Rec_0402167 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Herpes simplex virus 2; Huh7 cells
50 %
Virus infection inhibition at 10 μM
PaperPubMed PMID: 35663971 PMID35663971 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35663971/
RECORD: Rec_0426856 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxicity
Vero E6 cells
169.6±1.1 μM
CC50 / CCK-8 cytotoxicity assay
PaperPubMed PMID: 35663971 PMID35663971 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35663971/
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