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MYP_122201
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Basic Information
FP
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Anti-Flavivirus ▸ Anti-Dengue virus
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
19 amino acids
C118H197N35O21S
Standard
Sequence
MGRFKRFRKKFKKLFKKLS
Physicochemical Analysis
2474.11 Da
12.00
9.49
9.27
0.4996
-1.12
0.82
-0.54
-6.04
41.05
0.2105
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
975.19
-4.74
37.0
32.0
93.0
175.0
4.0
18.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0061873 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Cronobacter sakazakii
125 μg/mL
MIC
PMID30716944 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30716944/
RECORD: Rec_0080846 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PaperPubMed PMID: 35663971 PMID35663971 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35663971/
RECORD: Rec_0182657 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Dengue virus 2
50 %
Inhibition
PaperPubMed PMID: 35663971 PMID35663971 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35663971/
RECORD: Rec_0194147 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
SARS-CoV-2:inhibition of viral infection in Huh7 cells
80 %
Inhibition
PaperPubMed PMID: 35663971 PMID35663971 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35663971/
RECORD: Rec_0201117 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-DENV Infection inhibition
Dengue virus 2(DENV2) | Huh7 cells
10 μM
% inhibition
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperBomidin: An Optimized Antimicrobial Peptide With Broad Antiviral Activity Against Enveloped Viruses. | Liu R, Liu Z, Peng H, Lv Y, Feng Y, Kang J, Lu N, Ma R, Hou S, Sun W, Ying Q, Wang F, Gao Q, Zhao P, Zhu C, Wang Y, Wu X. | Front Immunol. 2022 May 19;13:851642. | DOI:10.3389/fimmu.2022.851642 | PMID:35663971 PMID35663971 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35663971/
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