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MYP_122189
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Basic Information
pAntp (43-58)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antiviral
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
16 amino acids
C104H168N34O20S
Standard
Sequence
RQIKIWFQNRRMKWKK
Physicochemical Analysis
2246.73 Da
12.00
6.76
6.55
0.4223
-1.73
0.38
-0.62
46.60
48.75
0.1875
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
950.45
-5.08
35.0
28.0
80.0
159.0
5.0
18.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0243966 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Biotinylation
Amidation
Bio-Activity Profile
Drug Delivery Vehicle Cell-penetrating peptide
PaperCPPsite: a curated database of cell penetrating peptides PMID22403286 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22403286/
RECORD: Rec_0253290 VERIFIED: YES
Provenance & Taxonomy
Drosophila melanogaster [Animal]
Penetratin
7227
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
Biotinylation
Amidation
N-term detail: Biotinylation; lowercase source residues at positions 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 denote stereochemical modification
Bio-Activity Profile
Cell-penetrating peptide
Cortical striatal cells
Cellular uptake assay
PMID8663410 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8663410/
RECORD: Rec_0263304 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus pseudintermedius MRSP
8 μM
MIC90
PMID25551573 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25551573/
RECORD: Rec_0263352 VERIFIED: YES
Provenance & Taxonomy
Drosophila melanogaster [Animal]
7227
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
28 μM
MIC
RECORD: Rec_0269073 VERIFIED: YES
Provenance & Taxonomy
Drosophila melanogaster [Animal]
Penetratin
7227
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Conjugation with nanoparticle
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PaperPreferential uptake of L- versus D-amino acid cell-penetrating peptides in a cell type-dependent manner PMID21867915 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21867915/
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