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MYP_122189
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Basic Information
pAntp (43-58)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antiviral
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
16 amino acids
C104H168N34O20S
Standard
Sequence
RQIKIWFQNRRMKWKK
Physicochemical Analysis
2246.73 Da
12.00
6.76
6.55
0.4223
-1.73
0.38
-0.62
46.60
48.75
0.1875
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
950.45
-5.08
35.0
28.0
80.0
159.0
5.0
18.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0219429 VERIFIED: NO
Provenance & Taxonomy
Drosophila melanogaster [Animal]
Penetratin
7227
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Fluorescein/FITC labeling
Amidation
N-term detail: Labelled with fluoresceine
Bio-Activity Profile
Cell-penetrating peptide
Human SH-SY5Y; N2A; Human bowes melanoma cells
Fluorescence-based uptake assay
Evidence URLhttps://crdd.osdd.net/raghava/cppsite/display.php?details=1479
RECORD: Rec_0223774 VERIFIED: YES
Provenance & Taxonomy
Drosophila melanogaster [Animal]
Penetratin
7227
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Fluorophore labeling
None
N-term detail: Rhodamine-labelled
Bio-Activity Profile
Cell-penetrating peptide
CHO K1; HeLa; A549 cells
Fluorescence-based uptake assay
PMID15937518 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15937518/
RECORD: Rec_0239977 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
RECORD: Rec_0243644 VERIFIED: NO
Provenance & Taxonomy
Synthetic construct [Synthetic]
Synthetic CPP
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Cell-penetrating peptide
9 L/LacZ cells
Cellular uptake assay
Evidence URLhttps://patents.google.com/patent/US20060035815 PatentUS20060035815
RECORD: Rec_0243899 VERIFIED: YES
Provenance & Taxonomy
Drosophila melanogaster [Animal]
Penetratin
7227
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
PEGylation
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PMID22841849 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22841849/
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