Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length456 amino acids

Chemical FormulaC2298H3630N624O646S9

DescriptionStandard

        TNPGFVVRITQAGLDYANQQGIAILEKELAQLRLPDISGDSRVLRVGKVHYSFSRLRLRDFHLPYSRITPISNVGLQVSISNAFAELDGDWRVKFLVVRDHGSFNLKLENVYIKISLRLGSDTAGKPTISTSDCRASISNVRVLFSGKFGWLYNLFHNTIESRLRKILEGKVCDNVVKSVENELHTYVRTLPVTARINDKIGIDYSLVAPPRATSQSLDTDLKGEFYSLAHRSTVPFSPLPLAFHSDHDRMVYFGASSYFFNTASIAYHKAGALVFEITEAMIPKDAGFSLDTSVFSAFIPQLEEMYPNMPMKFRLSAPTAPFLTIGPGGISFQPIVDAQAYAILPDASLAPLFLLSLVRNVSAVINVRSGHIVGSLDVGRIRLSLKNSAVGTFQVRTMQSLMNILASSTLLPRLNARLDEGFPLPLLERIQLSNIIVKFHQNFLLLGADVHFQPR
    

Molecular Weight50623.78 Da

Isoelectric Point (pI)9.44

Net Charge (pH 7.0)9.46

Net Charge (pH 7.4) 8.55

Charge Density (pH 7.0) 0.0208

GRAVY Index0.09

Hydrophobic Moment 0.67

Boman Index0.10

Instability Index32.88

Aliphatic Index 103.90

Aromaticity 0.0943

Extinction Coeff. Reduced 30370.00

Extinction Coeff. Oxidized 30495.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0008552 VERIFIED: NO

Provenance & Taxonomy

OrganismThryothorus ludovicianus [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria