MYP_121974
cBD103deltaG23
Antimicrobial
Standard
44 amino acids
C214H373N75O60S6
Standard
IINTLQRYYCRIRSGRCALLSCLPKEEQIGRCSSTGRKCCRRKK
5149.11 Da
10.10
9.70
9.40
0.2205
-0.66
0.75
-0.38
69.75
73.18
0.0455
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
2270.82
-27.00
91.0
76.0
180.0
355.0
3.0
46.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0072140
VERIFIED: YES
Provenance & Taxonomy
Canis lupus familiaris [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
APD analysis reveals this sequence is most similar (97.78%) to cBD103 GRAVY: -0.66; Mol formula: C214H374N74O60S6; Mol Wt: 5149.173, and Mol ex coeff.: 3355 (cys-paired). Chemical modification: 3 disulfide bonds: Cys1âCys5, Cys2âCys4, Cys3âCys6. AMP Significance: This is an important variant that is responsible for the black coat color of dogs. In particualr, CBD103 exhibits two types of genetic polymorphisms: (1) a variant allele with a 3-basepair deletion in its coding sequence, and (2) gene copy-number variation. The 3-basepair deletion in CBD103 , termed CBD103G23 , was identified as the allelic variant responsible for a dominant black coat color in dogs (Candille et al., 2007). CBD103 G23 lacks a glycine residue at the N-terminus of the mature peptide, and can bind with higher affinity than CBD103 to the melanocortin 1 receptor (Mc1r) on the surface of melanocytes. Due to its binding affinity and high expression levels, CBD103 G23 is thought to displace Agouti, an Mc1r signaling antagonist, allowing Mc1r to signal unabated, leading to the synthesis of the black pigment eumelanin and resulting in a black coat color. Additional details provided by Monique van Hoek. 2/2022
Bio-Activity Profile
Antimicrobial
S. pseudintermedius clinical strain, methicillin resistant
8 μM
MIC
RECORD: Rec_0143775
VERIFIED: YES
Provenance & Taxonomy
Canis lupus familiaris [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
APD analysis reveals this sequence is most similar (97.78%) to cBD103 GRAVY: -0.66; Mol formula: C214H374N74O60S6; Mol Wt: 5149.173, and Mol ex coeff.: 3355 (cys-paired). Chemical modification: 3 disulfide bonds: Cys1âCys5, Cys2âCys4, Cys3âCys6. AMP Significance: This is an important variant that is responsible for the black coat color of dogs. In particualr, CBD103 exhibits two types of genetic polymorphisms: (1) a variant allele with a 3-basepair deletion in its coding sequence, and (2) gene copy-number variation. The 3-basepair deletion in CBD103 , termed CBD103G23 , was identified as the allelic variant responsible for a dominant black coat color in dogs (Candille et al., 2007). CBD103 G23 lacks a glycine residue at the N-terminus of the mature peptide, and can bind with higher affinity than CBD103 to the melanocortin 1 receptor (Mc1r) on the surface of melanocytes. Due to its binding affinity and high expression levels, CBD103 G23 is thought to displace Agouti, an Mc1r signaling antagonist, allowing Mc1r to signal unabated, leading to the synthesis of the black pigment eumelanin and resulting in a black coat color. Additional details provided by Monique van Hoek. 2/2022
Bio-Activity Profile
Antimicrobial
E-coli ATCC 25922, or resistant clinical strains
>64 μM
MIC
RECORD: Rec_0175703
VERIFIED: YES
Provenance & Taxonomy
Canis lupus familiaris [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
APD analysis reveals this sequence is most similar (97.78%) to cBD103 GRAVY: -0.66; Mol formula: C214H374N74O60S6; Mol Wt: 5149.173, and Mol ex coeff.: 3355 (cys-paired). Chemical modification: 3 disulfide bonds: Cys1âCys5, Cys2âCys4, Cys3âCys6. AMP Significance: This is an important variant that is responsible for the black coat color of dogs. In particualr, CBD103 exhibits two types of genetic polymorphisms: (1) a variant allele with a 3-basepair deletion in its coding sequence, and (2) gene copy-number variation. The 3-basepair deletion in CBD103 , termed CBD103G23 , was identified as the allelic variant responsible for a dominant black coat color in dogs (Candille et al., 2007). CBD103 G23 lacks a glycine residue at the N-terminus of the mature peptide, and can bind with higher affinity than CBD103 to the melanocortin 1 receptor (Mc1r) on the surface of melanocytes. Due to its binding affinity and high expression levels, CBD103 G23 is thought to displace Agouti, an Mc1r signaling antagonist, allowing Mc1r to signal unabated, leading to the synthesis of the black pigment eumelanin and resulting in a black coat color. Additional details provided by Monique van Hoek. 2/2022
Bio-Activity Profile
Antimicrobial
E. faecium clinical isolate
8 μM
MIC
RECORD: Rec_0181545
VERIFIED: YES
Provenance & Taxonomy
Canis lupus familiaris [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
APD analysis reveals this sequence is most similar (97.78%) to cBD103 GRAVY: -0.66; Mol formula: C214H374N74O60S6; Mol Wt: 5149.173, and Mol ex coeff.: 3355 (cys-paired). Chemical modification: 3 disulfide bonds: Cys1âCys5, Cys2âCys4, Cys3âCys6. AMP Significance: This is an important variant that is responsible for the black coat color of dogs. In particualr, CBD103 exhibits two types of genetic polymorphisms: (1) a variant allele with a 3-basepair deletion in its coding sequence, and (2) gene copy-number variation. The 3-basepair deletion in CBD103 , termed CBD103G23 , was identified as the allelic variant responsible for a dominant black coat color in dogs (Candille et al., 2007). CBD103 G23 lacks a glycine residue at the N-terminus of the mature peptide, and can bind with higher affinity than CBD103 to the melanocortin 1 receptor (Mc1r) on the surface of melanocytes. Due to its binding affinity and high expression levels, CBD103 G23 is thought to displace Agouti, an Mc1r signaling antagonist, allowing Mc1r to signal unabated, leading to the synthesis of the black pigment eumelanin and resulting in a black coat color. Additional details provided by Monique van Hoek. 2/2022
Bio-Activity Profile
Antimicrobial
P-aeruginosa ATCC 27853, P-hauseri ATCC 13315, E-faecalis clinical isolate
>64 μM
MIC
RECORD: Rec_0206779
VERIFIED: YES
Provenance & Taxonomy
Canis lupus familiaris [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
APD analysis reveals this sequence is most similar (97.78%) to cBD103 GRAVY: -0.66; Mol formula: C214H374N74O60S6; Mol Wt: 5149.173, and Mol ex coeff.: 3355 (cys-paired). Chemical modification: 3 disulfide bonds: Cys1âCys5, Cys2âCys4, Cys3âCys6. AMP Significance: This is an important variant that is responsible for the black coat color of dogs. In particualr, CBD103 exhibits two types of genetic polymorphisms: (1) a variant allele with a 3-basepair deletion in its coding sequence, and (2) gene copy-number variation. The 3-basepair deletion in CBD103 , termed CBD103G23 , was identified as the allelic variant responsible for a dominant black coat color in dogs (Candille et al., 2007). CBD103 G23 lacks a glycine residue at the N-terminus of the mature peptide, and can bind with higher affinity than CBD103 to the melanocortin 1 receptor (Mc1r) on the surface of melanocytes. Due to its binding affinity and high expression levels, CBD103 G23 is thought to displace Agouti, an Mc1r signaling antagonist, allowing Mc1r to signal unabated, leading to the synthesis of the black pigment eumelanin and resulting in a black coat color. Additional details provided by Monique van Hoek. 2/2022
Bio-Activity Profile
Antimicrobial
S-aureus ATCC 25923, MRSA
>64 μM
MIC
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