Peptide Database

Peptide NameSLAY-screened peptide P5326

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC118H156N30O25S

DescriptionStandard

        GPFGFWLRPCHYHPLFSDHL
    

Molecular Weight2426.75 Da

Isoelectric Point (pI)7.01

Net Charge (pH 7.0)0.01

Net Charge (pH 7.4) -0.36

Charge Density (pH 7.0) 0.0006

GRAVY Index-0.20

Hydrophobic Moment 0.34

Boman Index0.23

Instability Index83.79

Aliphatic Index 58.50

Aromaticity 0.2500

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 831.34

LogP -2.51

H-bond Donors 29.0

H-bond Acceptors 29.0

Rotatable Bonds 66.0

Heavy Atoms 174.0

Ring Count 12.0

Amide Bonds 19.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0274840 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Familyp53-derived

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/