‹ ›
MYP_121957
← PREVIOUS NEXT → BACK
Basic Information
Pituitary adenylate cyclase-activating polypeptide 38
Antimicrobial
Antimicrobial ▸ Antifungal
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Chemokine signaling ▸ Chemokine-like peptide
Metabolic
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide signaling
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Reproductive biology ▸ Reproductive modulation
Standard
38 amino acids
C203H330N62O54S
Standard
Sequence
HSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNK
Physicochemical Analysis
4535.24 Da
10.41
8.84
8.57
0.2326
-1.06
0.56
-0.35
35.97
61.58
0.1316
5960.00
5960.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1964.15
-18.81
72.0
65.0
159.0
320.0
6.0
40.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0198120 VERIFIED: YES
Provenance & Taxonomy
Rattus norvegicus [Animal]
Pituitary adenylate cyclase-activating polypeptide
10116
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
27:Leucine amide
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Vasoactive Vasodilator Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation ACE inhibitory
chromaffin cells
Receptor functional assay (qualitative)
Experimental: 23±6 minutes; /1380 seconds; Mammalian: 3.5 hour; Yeast: 10 min; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Pituitary adenylate cyclase-activating polypeptide 38 (Rattus norvegicus): PMID 2803320##18353507 PMID2803320;18353507 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2803320/
RECORD: Rec_0206363 VERIFIED: NO
Provenance & Taxonomy
Mus musculus [Animal]
Pituitary adenylate cyclase-activating polypeptide
10090
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
27:Leucine amide
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Vasoactive Vasodilator Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation ACE inhibitory
Experimental: 23±6 minutes; /1380 seconds; Mammalian: 3.5 hour; Yeast: 10 min; E. coli: >10 hour
PaperNovel stable PACAP analogs with potent activity towards the PAC1 receptor PMID18353507 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18353507/
RECORD: Rec_0215480 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Pituitary adenylate cyclase-activating polypeptide
9823
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
27:Leucine amide
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation ACE inhibitory
secretion by pancreatic beta cells
Receptor functional assay (qualitative)
Experimental: 23±6 minutes; /1380 seconds; Mammalian: 3.5 hour; Yeast: 10 min; E. coli: >10 hour
PaperNovel stable PACAP analogs with potent activity towards the PAC1 receptor PMID18353507 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18353507/
RECORD: Rec_0216619 VERIFIED: YES
Provenance & Taxonomy
Ovis aries [Animal]
Pituitary adenylate cyclase-activating polypeptide
9940
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
27:Leucine amide
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation ACE inhibitory
chromaffin cells
Receptor functional assay (qualitative)
Experimental: 23±6 minutes; /1380 seconds; Mammalian: 3.5 hour; Yeast: 10 min; E. coli: >10 hour
PaperNovel stable PACAP analogs with potent activity towards the PAC1 receptor PMID18353507 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18353507/
RECORD: Rec_0221767 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Escherichia coli 43889, Staphylococcus aureus USA300, and Pseudomonas aeruginosa PAO1
2-10 μM
MBC
PaperPituitary adenylate cyclase-activating polypeptide is a potent broad-spectrum antimicrobial peptide: Structure-activity relationships PMID30462698 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30462698/
FIRST PREV 1 ... 4 5 6 7 8 ... 11 NEXT LAST
Showing 5 records · Page 6 of 11