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MYP_121957
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Basic Information
Pituitary adenylate cyclase-activating polypeptide 38
Antimicrobial
Antimicrobial ▸ Antifungal
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Chemokine signaling ▸ Chemokine-like peptide
Metabolic
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide signaling
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Reproductive biology ▸ Reproductive modulation
Standard
38 amino acids
C203H330N62O54S
Standard
Sequence
HSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNK
Physicochemical Analysis
4535.24 Da
10.41
8.84
8.57
0.2326
-1.06
0.56
-0.35
35.97
61.58
0.1316
5960.00
5960.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1964.15
-18.81
72.0
65.0
159.0
320.0
6.0
40.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0083921 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
Pituitary adenylate cyclase-activating polypeptide
10090
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
27:Leucine amide
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Vasoactive Vasodilator Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation ACE inhibitory
its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells
Experimental: 23±6 minutes; /1380 seconds; Mammalian: 3.5 hour; Yeast: 10 min; E. coli: >10 hour
PaperNovel stable PACAP analogs with potent activity towards the PAC1 receptor PMID18353507 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18353507/
RECORD: Rec_0101844 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
PACAP
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Hexanoylation
Amidation
Bio-Activity Profile
Neuroprotective
0.0083±0.0018 μM
IC50
DPP IV, in vitro; >14400 s
PaperNovel stable PACAP analogs with potent activity towards the PAC1 receptor PMID18353507 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18353507/
RECORD: Rec_0102367 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Pituitary adenylate cyclase-activating polypeptide
9823
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
27:Leucine amide
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation ACE inhibitory
chromaffin cells
Experimental: 23±6 minutes; /1380 seconds; Mammalian: 3.5 hour; Yeast: 10 min; E. coli: >10 hour
PaperNovel stable PACAP analogs with potent activity towards the PAC1 receptor PMID18353507 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18353507/
RECORD: Rec_0103721 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Pseudomonas aeruginosa
1.2 μM
MIC
PaperPituitary adenylate cyclase-activating polypeptide is a potent broad-spectrum antimicrobial peptide: Structure-activity relationships PMID30462698 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30462698/
RECORD: Rec_0105500 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
PACAP
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Neuroprotective
0.0029±0.0009 μM
IC50
DPP IV, in vitro; >14400 s
PaperNovel stable PACAP analogs with potent activity towards the PAC1 receptor PMID18353507 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18353507/
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