Peptide Database

Peptide NamePituitary adenylate cyclase-activating polypeptide 38

Function Ontology

Antimicrobial

Antimicrobial ▸ Antifungal

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity

Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier

Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide

Delivery / Targeting ▸ Drug delivery vehicle

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Hormonal / Endocrine ▸ Hormone peptide

Immunology ▸ Chemokine signaling ▸ Chemokine-like peptide

Metabolic

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide signaling

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Regulatory peptide ▸ Cell-cell communication

Reproductive biology ▸ Reproductive modulation

Standard StatusStandard

Sequence Length38 amino acids

Chemical FormulaC203H330N62O54S

DescriptionStandard

        HSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNK
    

Molecular Weight4535.24 Da

Isoelectric Point (pI)10.41

Net Charge (pH 7.0)8.84

Net Charge (pH 7.4) 8.57

Charge Density (pH 7.0) 0.2326

GRAVY Index-1.06

Hydrophobic Moment 0.56

Boman Index-0.35

Instability Index35.97

Aliphatic Index 61.58

Aromaticity 0.1316

Extinction Coeff. Reduced 5960.00

Extinction Coeff. Oxidized 5960.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1964.15

LogP -18.81

H-bond Donors 72.0

H-bond Acceptors 65.0

Rotatable Bonds 159.0

Heavy Atoms 320.0

Ring Count 6.0

Amide Bonds 40.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0417441 VERIFIED: YES

Provenance & Taxonomy

OrganismOvis aries [Animal]

FamilyPituitary adenylate cyclase-activating polypeptide

Tax ID9940

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Other Mods27:Leucine amide

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation ACE inhibitory

Targetsecretion by pancreatic beta cells

Half-LifeExperimental: 23±6 minutes; /1380 seconds; Mammalian: 3.5 hour; Yeast: 10 min; E. coli: >10 hour

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